Rozatin 20
(2 customer reviews)

Rozatin

Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate, a precursor for cholesterol. The primary site of action of rosuvastatin is the liver, the target organ for cholesterol lowering. Rosuvastatin increases the number of hepatic LDL receptors on the cellsurface, enhancing uptake and catabolism of LDL and it inhibits the hepatic synthesis of VLDL, thereby reducing the total number of VLDL and LDL particles.


Composition

Each film coated tablet contains:

Rosuvastatin Calcium  Equivalent to Rosuvastatin    5 mg/ 10 mg/20 mg

Excipients    q.s.

Indications

Treatment of hypercholesterolaemia and Prevention of Cardiovascular Events

Dosage

Treatment of hypercholesterolaemia.-

The recommended start dose is 5 mg or 10 mg orally once daily. 40 mg should only be considered in patients with severe hypercholesterolaemia at high cardiovascular risk.

Prevention of cardiovascular events-

In the cardiovascular events risk reduction study, the dose used was 20 mg daily.

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