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Valclov 500

Valacyclovir an antiviral is the L-valine ester of Acyclovir. Acyclovir is a purine (guanine) nucleoside analogue. Valacyclovir is rapidly and almost completely converted in man to acyclovir and valine, probably by the enzyme referred to as valacyclovir hydrolase. Acyclovir is a specific inhibitor of the herpes viruses with in vitro activity against herpes simplex viruses (HSV) type 1 and type 2, varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr Virus (EBV), and human herpes virus 6 (HHV-6). Acyclovir inhibits herpes virus DNA synthesis once it has been phosphorylated to the active triphosphate form. The first stage of phosphorylation requires the activity of a virus-specific enzyme. In the case of HSV, VZV and EBV this enzyme is the viral thymidine kinase (TK), which is only present in virus-infected cells. Selectivity is maintained in CMV with phosphorylation, at least in part, being mediated through the phosphotransferase gene product of UL97. This requirement for activation of aciclovir by a virus-specific enzyme largely explains its selectivity.


Each Film-Coated Tablet Contains:

Valacyclovir Hydrochloride equivalent to Valacyclovir …….500 mg

Excipients: ….q.s.


For the treatment of herpes zoster (shingles) in adult patients who commence therapy within 72 hours of the onset of rash.

  • -For the treatment of ophthalmic zoster.
  • -For the treatment of recurrent herpes labialis (cold sores)
  • -For the treatment of clinical episodes of genital herpes simplex infections.
  • -For the prevention of recurrent genital herpes.
  • -Reduction of transmission of genital herpes in patients suffering from recurrent genital herpes. In addition to therapy with Valacyclovir, it is recommended that patients use safer sex practices.
  • -Prophylaxis of cytomegalovirus (CMV) infection and disease following solid organ transplantation in patients at risk of CMV disease.


  • -For treatment of herpes zoster, 1000 mg of Valacyclovir three times a day for seven days.
  • -The recommended dosage of Valacyclovir for the treatment of cold sores is 2000 mg twice daily for 1 day with the second dose taken about 12 hours (no sooner than 6 hours) after the first dose. Therapy should be initiated at the earliest symptom of a cold sore (e.g. tingling, itching, or burning).
  • -For treatment of first clinical presentation of genital herpes, 500 mg of Valacyclovir twice a day for 5 to 10 days.
  • -For recurrent episodes of genital herpes, 500 mg twice daily for 5 days. Dosing should begin as early as possible. For recurrent episodes of genital herpes, this should ideally be during the prodromal period or immediately following the appearance of the first signs or symptoms.
  • -For the prevention of genital herpes in patients with a history of fewer than 10 recurrences each year, 500mg of Valacyclovir once daily, either as a single dose or a divided dose.
  • -For the prevention of genital herpes in patients with a history of 10 or more recurrences each year when not taking suppressive therapy, 1000mg of Valacyclovir once daily.
  • -For immunocompromised patients, 500 mg twice daily.
  • -Reduction of transmission of genital herpes: In immunocompetent heterosexual adults with less than 10 recurrences per year and with the susceptible partner discordant for HSV-2 antibodies, 500mg of Valacyclovir to be taken once daily by the infected partner.
  • -For the prophylaxis of cytomegalovirus infection (CMV) and disease: Dosage of Valacyclovir in adults and adolescents (from 12 years of age) is 2 g four times a day for 90 days, to be initiated as early as possible post-transplant. This dose should be reduced according to creatinine clearance (see Dosage in renal impairment)

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