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Desmopressin is a synthetic analogue of vasopressin. Desmopressin is a selective agonist at V2 receptors on renal cells in the collecting ducts, increasing water re-absorption in the kidneys, and reducing urine production.


Each spray delivers Desmopressin acetate  10 mg

Desmopressin acetate   0.01 % w/v

Eq to Desmopressin  BP – 0.0089 w/v

Benzalkonium chloride solution BP – 0.02% W/V

Excipients— q s


For the treatment of nocturia due to nocturnal polyuria in adults who awaken at least 2 times per night to void.


  • For patients < 65 years of age who are not at increased risk for hyponatremia: Use one spray of 1.66 mcg in either nostril nightly approximately 30 minutes before going to bed.
  • For patients ≥ 65 years of age or younger patients at risk for hyponatremia: Use 0.83 mcg nightly, which can be increased to one spray of 1.66 mcg after at least 7 days, if needed, provided the serum sodium has remained normal.

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