Tiodora 18
(2 customer reviews)

Tiodora 18

Tiotropium binds with high affinity to muscarinic M2 Receptors , thus preventing them from  activating the signal transduction pathway involving Gq protein and phospholipase C. As a consequence ,the synthesis of intracellular second messenger inositol I 4,5-Triphosphate (IP3) is supressed . Therefore blockage of M3 receptors by tiotropium  results in effective inhibition of bronchoconstriction mediated by IP3-Dependent Ca++ Mobilization.


Composition

Each Capsule Contains:

Tiotropium Bromide BP          18 mcg

Excipients      q.s.

Indication

Tiotropium is an anticholinergic indicated for the long-term, once-daily, maintenance treatment of bronchospasm associated with COPD and for reducing COPD exacerbations.

Dosage

Two inhalations of the powder contents of a single Tiodora capsule (18 mcg) once daily

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